ABSTRACT
Introduction: Chronic liver disease is a disorder in whichprogressive destruction of liver parenchyma leads to fibrosisand lead to cirrhosis. Increased level of serum uric acid may because insulin resistance, metabolic syndrome and oxidativestress which are the risk factors for progression of liverdisease.Objective: To estimate the levels of uric acid and evaluate itsassociation with the severity of liver disease.Methods: One hundred fifty patients diagnosed with Chronicliver disease, age between 20 to 65 years, either gender, wereenrolled in the study. Patients were grouped as classes A, Band C on the basis of Child Pugh score. Serum uric acid wasestimated and compared among the three groups.Result: Analysis of Variance (ANOVA) was applied and it wasobserved that there was a significant elevation of serum uricacid level with the progression of disease (P = <0.001). Apositive association of uric acid on applying Spearman’scorrelation, with progression of Child Pugh score was alsoobserved (r = 0.293; P = <0.001)